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RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.64, somatic mutation 0.98).
In plain words · RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments.
No product in this corpus aims at RAD51B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-specific alteration: the catalogues call it a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA RAD51B: RNA low tissue specificity; high antibody staining in 40 normal tissues; highest cancer staining thyroid cancer (4 of 4 high). Distribution: 5 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Prostate cancer, Ovarian cancer, Lung cancer (all types), Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt O15315; CIViC gene RAD51B; Human Protein Atlas RAD51B tissue; Open Targets ENSG00000182185 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Rice M.C. et al, Proc. Natl. Acad. Sci. U.S.A, 1997, "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Source.
Sources: HGNC HGNC:9822 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15315 (protein name, function text, keywords and locations (REST API)); CIViC gene RAD51B (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000182185 (association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: prostate cancer 0.52, ovarian cancer 0.56, skin cancer 0.52, breast cancer 0.68, lung cancer 0.54 (GraphQL API, CC0))
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. Location: Nucleus (UniProt). Locus 14q24.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Heart muscle, Prostate, Vagina.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RAD51B" OR ABSTRACT:"RAD51B" OR TITLE:"RAD51 paralog B" OR ABSTRACT:"RAD51 paralog B" OR TITLE:"DNA repair protein RAD51 homolog 2" OR ABSTRACT:"DNA repair protein RAD51 homolog 2" OR TITLE:"REC2" OR ABSTRACT:"REC2" OR TITLE:"hREC2" OR ABSTRACT:"hREC2" OR TITLE:"R51H2" OR ABSTRACT:"R51H2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD51B, not a curated reading list.