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RAD23B (Lysine-specific demethylase RAD23B) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas.
Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vorinostat.
In plain words · RAD23B (Lysine-specific demethylase RAD23B) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas.
RAD23B (Lysine-specific demethylase RAD23B) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas.
Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation.
No product in this corpus aims at RAD23B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RAD23B: RNA low tissue specificity; high antibody staining in 37 normal tissues; highest cancer staining prostate cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RAD23B tissue; Open Targets ENSG00000119318 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Masutani et al, EMBO J, 1994, "Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". Source.
Sources: HGNC HGNC:9813 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P54727 (protein name, function text, keywords and locations (REST API)); CIViC gene RAD23B (1 evidence items, 0 assertions, 1 variants; diseases: Sarcoma (GraphQL API, CC0))
Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Location: Nucleus; Cytoplasm (UniProt). Locus 9q31.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Caudate, Heart muscle, Lung, Lymph node, Skeletal muscle, Smooth muscle, Spleen.
Medium only: melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RAD23B" OR ABSTRACT:"RAD23B" OR TITLE:"RAD23 nucleotide excision repair protein B" OR ABSTRACT:"RAD23 nucleotide excision repair protein B" OR TITLE:"Lysine-specific demethylase RAD23B" OR ABSTRACT:"Lysine-specific demethylase RAD23B" OR TITLE:"HHR23B" OR ABSTRACT:"HHR23B" OR TITLE:"P58" OR ABSTRACT:"P58" OR TITLE:"HR23B" OR ABSTRACT:"HR23B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD23B, not a curated reading list.