{"entity":{"id":"rad23b","kind":"target","name":"RAD23B","aka":["RAD23 nucleotide excision repair protein B","Lysine-specific demethylase RAD23B","HHR23B","P58","HR23B"],"tldr":"RAD23B (Lysine-specific demethylase RAD23B) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas.","summary":"Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vorinostat.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9813","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9813"},{"label":"UniProt P54727","url":"https://www.uniprot.org/uniprotkb/P54727/entry"},{"label":"NCBI Gene 5887","url":"https://www.ncbi.nlm.nih.gov/gene/5887"},{"label":"Ensembl ENSG00000119318","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119318"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RAD23B","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9813","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9813","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P54727","url":"https://www.uniprot.org/uniprotkb/P54727/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RAD23B","url":"https://civicdb.org/features/4760","note":"1 evidence items, 0 assertions, 1 variants; diseases: Sarcoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RAD23B: RNA low tissue specificity; high antibody staining in 37 normal tissues; highest cancer staining prostate cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RAD23B tissue","url":"https://www.proteinatlas.org/ENSG00000119318-RAD23B/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000119318 associations","url":"https://platform.opentargets.org/target/ENSG00000119318/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9813","ensembl":"ENSG00000119318","uniprot":"P54727","entrez":"5887","firstDescribed":1994,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Masutani et al, EMBO J, 1994, \"Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8168482/","biology":"Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Location: Nucleus; Cytoplasm (UniProt). Locus 9q31.2 (HGNC).","whereFound":["Sarcomas: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rad23b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}