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PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.
In plain words · PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Probable oxidoreductase. Lacks peroxidase activity.
No product in this corpus aims at PXDNL yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PXDNL: RNA tissue enriched (heart muscle 43 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PXDNL tissue; Open Targets ENSG00000147485 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:26359 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A1KZ92 (protein name, function text, keywords and locations (REST API)); CIViC gene PXDNL (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction. Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. Location: Secreted; Endoplasmic reticulum; Cell membrane; Cytoplasm (UniProt). Locus 8q11.22-q11.23 (HGNC).
RNA: tissue enriched (heart muscle 43 nTPM), detected in some normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PXDNL" OR ABSTRACT:"PXDNL" OR TITLE:"peroxidasin like" OR ABSTRACT:"peroxidasin like" OR TITLE:"Probable oxidoreductase PXDNL" OR ABSTRACT:"Probable oxidoreductase PXDNL" OR TITLE:"FLJ25471" OR ABSTRACT:"FLJ25471" OR TITLE:"PMR1" OR ABSTRACT:"PMR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PXDNL, not a curated reading list.