{"entity":{"id":"pxdnl","kind":"target","name":"PXDNL","aka":["peroxidasin like","Probable oxidoreductase PXDNL","FLJ25471","PMR1"],"tldr":"PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:26359","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26359"},{"label":"UniProt A1KZ92","url":"https://www.uniprot.org/uniprotkb/A1KZ92/entry"},{"label":"NCBI Gene 137902","url":"https://www.ncbi.nlm.nih.gov/gene/137902"},{"label":"Ensembl ENSG00000147485","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147485"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PXDNL","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:26359","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26359","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A1KZ92","url":"https://www.uniprot.org/uniprotkb/A1KZ92/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PXDNL","url":"https://civicdb.org/features/18364","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PXDNL: RNA tissue enriched (heart muscle 43 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PXDNL tissue","url":"https://www.proteinatlas.org/ENSG00000147485-PXDNL/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000147485 associations","url":"https://platform.opentargets.org/target/ENSG00000147485/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:26359","ensembl":"ENSG00000147485","uniprot":"A1KZ92","entrez":"137902","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, \"Complete sequencing and characterization of 21,243 full-length human cDNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14702039/","biology":"Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction. Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. Location: Secreted; Endoplasmic reticulum; Cell membrane; Cytoplasm (UniProt). Locus 8q11.22-q11.23 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/pxdnl/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}