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PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins.
No product in this corpus aims at PTTG1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PTTG1 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PTTG1: RNA tissue enhanced (bone marrow 151 nTPM, lymphoid tissue 135 nTPM, testis 164 nTPM); blood lineage lineage enriched (T-cells 219 nTPM); high antibody staining in 3 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PTTG1 tissue; Open Targets ENSG00000164611 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Dominguez et al, Oncogene, 1998, "hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG". Source.
Sources: HGNC HGNC:9690 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95997 (protein name, function text, keywords and locations (REST API)); CIViC gene PTTG1 (1 evidence items, 0 assertions, 1 variants; diseases: Meningioma (GraphQL API, CC0))
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. Location: Cytoplasm; Nucleus (UniProt). Locus 5q33.3 (HGNC).
RNA: tissue enhanced (bone marrow 151 nTPM, lymphoid tissue 135 nTPM, testis 164 nTPM), detected in all normal tissues. Blood: lineage enriched (T-cells 219 nTPM).
Medium: Appendix, Bone marrow, Breast, Bronchus, Cervix, Esophagus, Nasopharynx, Oral mucosa.
No cancer stained high; medium in breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
HPA PTTG1 tissue · HPA PTTG1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PTTG1" OR ABSTRACT:"PTTG1" OR TITLE:"PTTG1 regulator of sister chromatid separation, securin" OR ABSTRACT:"PTTG1 regulator of sister chromatid separation, securin" OR TITLE:"Securin" OR ABSTRACT:"Securin" OR TITLE:"HPTTG" OR ABSTRACT:"HPTTG" OR TITLE:"EAP1" OR ABSTRACT:"EAP1" OR TITLE:"securin" OR ABSTRACT:"securin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTTG1, not a curated reading list.
Shares Meningioma, CIViC.
Shares Meningioma, CIViC.