{"entity":{"id":"pttg1","kind":"target","name":"PTTG1","aka":["PTTG1 regulator of sister chromatid separation, securin","Securin","HPTTG","EAP1","securin","ECRAR","TUTR1"],"tldr":"PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.","summary":"Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9690","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9690"},{"label":"UniProt O95997","url":"https://www.uniprot.org/uniprotkb/O95997/entry"},{"label":"NCBI Gene 9232","url":"https://www.ncbi.nlm.nih.gov/gene/9232"},{"label":"Ensembl ENSG00000164611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164611"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["meningioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTTG1","role":["biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9690","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9690","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95997","url":"https://www.uniprot.org/uniprotkb/O95997/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTTG1","url":"https://civicdb.org/features/7297","note":"1 evidence items, 0 assertions, 1 variants; diseases: Meningioma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists PTTG1 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PTTG1: RNA tissue enhanced (bone marrow 151 nTPM, lymphoid tissue 135 nTPM, testis 164 nTPM); blood lineage lineage enriched (T-cells 219 nTPM); high antibody staining in 3 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas PTTG1 tissue","url":"https://www.proteinatlas.org/ENSG00000164611-PTTG1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000164611 associations","url":"https://platform.opentargets.org/target/ENSG00000164611/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9690","ensembl":"ENSG00000164611","uniprot":"O95997","entrez":"9232","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Dominguez et al, Oncogene, 1998, \"hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9811450/","biology":"Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. Location: Cytoplasm; Nucleus (UniProt). Locus 5q33.3 (HGNC).","whereFound":["Meningioma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/pttg1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"meningioma","kind":"cancer","name":"Meningioma","route":"/cancers/meningioma/"}]}}