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PSMB11 (Proteasome subunit beta type-11) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.12, animal model 0.43, clinical 0.99).
In plain words · PSMB11 (Proteasome subunit beta type-11) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
PSMB11 (Proteasome subunit beta type-11) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
No product in this corpus aims at PSMB11 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSMB11: RNA tissue enriched (lymphoid tissue 29 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Multiple myeloma, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, mantle cell lymphoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PSMB11 tissue; Open Targets ENSG00000222028 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Heilig et al, Nature, 2003, "The DNA sequence and analysis of human chromosome 14". Source.
Sources: HGNC HGNC:31963 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A5LHX3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000222028 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.58, mantle cell lymphoma 0.54 (GraphQL API, CC0))
The proteasome is a multicatalytic proteinase complex which is characterised by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T cells. Location: Cytoplasm; Nucleus (UniProt). Locus 14q11.2 (HGNC).
RNA: tissue enriched (lymphoid tissue 29 nTPM), detected in single normal tissue.
No normal tissue stained high; medium in Thymus.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSMB11" OR ABSTRACT:"PSMB11" OR TITLE:"proteasome subunit beta 11" OR ABSTRACT:"proteasome subunit beta 11" OR TITLE:"Proteasome subunit beta type-11" OR ABSTRACT:"Proteasome subunit beta type-11" OR TITLE:"beta5t" OR ABSTRACT:"beta5t") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSMB11, not a curated reading list.