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PSENEN (Gamma-secretase subunit PEN-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
In plain words · PSENEN (Gamma-secretase subunit PEN-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
PSENEN (Gamma-secretase subunit PEN-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).
No product in this corpus aims at PSENEN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSENEN: RNA tissue enhanced (choroid plexus 320 nTPM); high antibody staining in 10 normal tissues; highest cancer staining melanoma (2 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 1 specific cancer type at or above 0.5 (desmoid tumor). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PSENEN tissue; Open Targets ENSG00000205155 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Zhao et al, 1999, "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients". Source.
Sources: HGNC HGNC:30100 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NZ42 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205155 (per-cancer scores at or above 0.5: desmoid tumour 0.50 (GraphQL API, CC0))
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Besides its role in gamma-secretase complex, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds metformin, an antidiabetic drug, promoting association with ATP6AP1, a subunit of the V-ATPase complex, leading to V-ATPase complex inhibition on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis. Location: Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane; Cell membrane; Membrane (UniProt). Locus 19q13.12 (HGNC).
RNA: tissue enhanced (choroid plexus 320 nTPM), detected in all normal tissues.
Medium: Appendix, Bone marrow, Breast, Caudate, Cervix, Colon, Duodenum, Endometrium.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSENEN" OR ABSTRACT:"PSENEN" OR TITLE:"presenilin enhancer, gamma-secretase subunit" OR ABSTRACT:"presenilin enhancer, gamma-secretase subunit" OR TITLE:"Gamma-secretase subunit PEN-2" OR ABSTRACT:"Gamma-secretase subunit PEN-2" OR TITLE:"PEN2" OR ABSTRACT:"PEN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSENEN, not a curated reading list.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.