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NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
In plain words · NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).
No product in this corpus aims at NCSTN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NCSTN: RNA low tissue specificity; high antibody staining in 3 normal tissues; highest cancer staining melanoma (1 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 1 specific cancer type at or above 0.5 (desmoid tumor). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NCSTN tissue; Open Targets ENSG00000162736 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". Source.
Sources: HGNC HGNC:17091 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92542 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162736 (per-cancer scores at or above 0.5: desmoid tumour 0.50 (GraphQL API, CC0))
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Location: Membrane; Cytoplasmic vesicle membrane; Melanosome (UniProt). Locus 1q23.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bronchus, Cerebellum, Cerebral cortex, Cervix, Colon, Duodenum.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NCSTN" OR ABSTRACT:"NCSTN" OR TITLE:"nicastrin" OR ABSTRACT:"nicastrin" OR TITLE:"Nicastrin" OR ABSTRACT:"Nicastrin" OR TITLE:"KIAA0253" OR ABSTRACT:"KIAA0253" OR TITLE:"APH2" OR ABSTRACT:"APH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCSTN, not a curated reading list.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.
Shares Desmoid tumour, Open Targets Platform.