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PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, genetic association 0.69, clinical 0.17).
In plain words · PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
No product in this corpus aims at PSCA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSCA: RNA tissue enriched (stomach 1 3,010 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PSCA tissue; Open Targets ENSG00000167653 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Reiter R.E. et al, Proc. Natl. Acad. Sci. U.S.A, 1998, "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer". Source.
Sources: HGNC HGNC:9500 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43653 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167653 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: gastric cancer 0.53 (GraphQL API, CC0))
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signalling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. Location: Cell membrane (UniProt). Locus 8q24.3 (HGNC).
RNA: tissue enriched (stomach 1 3,010 nTPM), detected in many normal tissues.
No normal tissue stained high.
RNA cancer enriched: Bladder Urothelial Carcinoma 1,552 pTPM.
No cancer stained high; medium in stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PSCA" OR ABSTRACT:"PSCA" OR TITLE:"prostate stem cell antigen" OR ABSTRACT:"prostate stem cell antigen" OR TITLE:"Prostate stem cell antigen" OR ABSTRACT:"Prostate stem cell antigen" OR TITLE:"lncPSCA" OR ABSTRACT:"lncPSCA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSCA, not a curated reading list.