{"entity":{"id":"psca","kind":"target","name":"PSCA","aka":["prostate stem cell antigen","Prostate stem cell antigen","lncPSCA"],"tldr":"PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, genetic association 0.69, clinical 0.17).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9500"},{"label":"UniProt O43653","url":"https://www.uniprot.org/uniprotkb/O43653/entry"},{"label":"NCBI Gene 8000","url":"https://www.ncbi.nlm.nih.gov/gene/8000"},{"label":"Ensembl ENSG00000167653","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167653"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.17. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PSCA","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9500","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43653","url":"https://www.uniprot.org/uniprotkb/O43653/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000167653","url":"https://platform.opentargets.org/target/ENSG00000167653/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: gastric cancer 0.53 (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PSCA: RNA tissue enriched (stomach 1 3,010 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PSCA tissue","url":"https://www.proteinatlas.org/ENSG00000167653-PSCA/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000167653 associations","url":"https://platform.opentargets.org/target/ENSG00000167653/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9500","ensembl":"ENSG00000167653","uniprot":"O43653","entrez":"8000","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Reiter R.E. et al, Proc. Natl. Acad. Sci. U.S.A, 1998, \"Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9465086/","biology":"May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signalling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. Location: Cell membrane (UniProt). Locus 8q24.3 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.53 with gastric cancer (MONDO_0001056)"],"targetClass":"other","prevalence":[]},"route":"/targets/psca/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}