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PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.
In plain words · PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells.
No product in this corpus aims at PROM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PROM1: RNA tissue enriched (retina 253 nTPM); high antibody staining in 6 normal tissues; highest cancer staining colorectal cancer (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PROM1 tissue; Open Targets ENSG00000007062 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Miraglia et al, Blood, 1997, "A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning". Source.
Sources: HGNC HGNC:9454 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43490 (protein name, function text, keywords and locations (REST API)); CIViC gene PROM1 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signalling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Location: Apical cell membrane; Cell projection, microvillus membrane; Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum (UniProt). Locus 4p15.32 (HGNC).
RNA: tissue enriched (retina 253 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Appendix, Breast, Colon, Duodenum, Epididymis, Liver, Nasopharynx.
Medium only: carcinoid, head and neck cancer.
HPA PROM1 tissue · HPA PROM1 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PROM1" OR ABSTRACT:"PROM1" OR TITLE:"prominin 1" OR ABSTRACT:"prominin 1" OR TITLE:"Prominin-1" OR ABSTRACT:"Prominin-1" OR TITLE:"AC133" OR ABSTRACT:"AC133" OR TITLE:"CD133" OR ABSTRACT:"CD133" OR TITLE:"RP41" OR ABSTRACT:"RP41") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PROM1, not a curated reading list.