{"entity":{"id":"prom1","kind":"target","name":"PROM1","aka":["prominin 1","Prominin-1","AC133","CD133","RP41","CORD12","PROML1","MCDR2","STGD4"],"tldr":"PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.","summary":"May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9454","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9454"},{"label":"UniProt O43490","url":"https://www.uniprot.org/uniprotkb/O43490/entry"},{"label":"NCBI Gene 8842","url":"https://www.ncbi.nlm.nih.gov/gene/8842"},{"label":"Ensembl ENSG00000007062","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000007062"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PROM1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9454","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9454","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43490","url":"https://www.uniprot.org/uniprotkb/O43490/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PROM1","url":"https://civicdb.org/features/7014","note":"1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PROM1: RNA tissue enriched (retina 253 nTPM); high antibody staining in 6 normal tissues; highest cancer staining colorectal cancer (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PROM1 tissue","url":"https://www.proteinatlas.org/ENSG00000007062-PROM1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000007062 associations","url":"https://platform.opentargets.org/target/ENSG00000007062/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9454","ensembl":"ENSG00000007062","uniprot":"O43490","entrez":"8842","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Miraglia et al, Blood, 1997, \"A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9389721/","biology":"May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signalling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Location: Apical cell membrane; Cell projection, microvillus membrane; Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum (UniProt). Locus 4p15.32 (HGNC).","whereFound":["Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/prom1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}