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PPP2R5C (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.82, genetic association 0.00, somatic mutation 0.23, animal model 0.32). In OnCo, 1 product record names it (Cologuard Plus).
In plain words · PPP2R5C (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
PPP2R5C (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment.
No product in this corpus aims at PPP2R5C yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Cologuard Plus) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA PPP2R5C: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PPP2R5C tissue; Open Targets ENSG00000078304 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Nomura et al, DNA Res, 1994, "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:9311 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13362 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078304 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation. Location: Nucleus; Chromosome, centromere (UniProt). Locus 14q32.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Breast, Bronchus, Cerebellum, Cerebral cortex, Cervix, Colon, Duodenum.
No cancer stained high; medium in breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PPP2R5C" OR ABSTRACT:"PPP2R5C" OR TITLE:"protein phosphatase 2 regulatory subunit B'gamma" OR ABSTRACT:"protein phosphatase 2 regulatory subunit B'gamma" OR TITLE:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform" OR TITLE:"B56G" OR ABSTRACT:"B56G" OR TITLE:"PR61G" OR ABSTRACT:"PR61G" OR TITLE:"B56gamma" OR ABSTRACT:"B56gamma") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R5C, not a curated reading list.