{"entity":{"id":"ppp2r5c","kind":"target","name":"PPP2R5C","aka":["protein phosphatase 2 regulatory subunit B'gamma","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform","B56G","PR61G","B56gamma"],"tldr":"PPP2R5C (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.82, genetic association 0.00, somatic mutation 0.23, animal model 0.32). In OnCo, 1 product record names it (Cologuard Plus).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9311","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9311"},{"label":"UniProt Q13362","url":"https://www.uniprot.org/uniprotkb/Q13362/entry"},{"label":"NCBI Gene 5527","url":"https://www.ncbi.nlm.nih.gov/gene/5527"},{"label":"Ensembl ENSG00000078304","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078304"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["cologuard-plus"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2R5C","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9311","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9311","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13362","url":"https://www.uniprot.org/uniprotkb/Q13362/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000078304","url":"https://platform.opentargets.org/target/ENSG00000078304/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"not-established","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Cologuard Plus) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA PPP2R5C: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas PPP2R5C tissue","url":"https://www.proteinatlas.org/ENSG00000078304-PPP2R5C/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000078304 associations","url":"https://platform.opentargets.org/target/ENSG00000078304/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:9311","ensembl":"ENSG00000078304","uniprot":"Q13362","entrez":"5527","firstDescribed":1994,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nomura et al, DNA Res, 1994, \"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7584044/","biology":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation. Location: Nucleus; Chromosome, centromere (UniProt). Locus 14q32.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ppp2r5c/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"drug":[{"id":"cologuard-plus","kind":"drug","name":"Cologuard Plus","route":"/drugs/cologuard-plus/"}]}}