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POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.36, genetic association 0.00, somatic mutation 0.93).
In plain words · POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').
No product in this corpus aims at POU5F1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA POU5F1: RNA tissue enhanced (kidney 17 nTPM); high antibody staining in 3 normal tissues; highest cancer staining carcinoid (1 of 4 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas POU5F1 tissue; Open Targets ENSG00000204531 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Takeda et al, Nucleic Acids Res, 1992, "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues". Source.
Sources: HGNC HGNC:9221 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01860 (protein name, function text, keywords and locations (REST API)); CIViC gene POU5F1 (1 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer (GraphQL API, CC0)); Open Targets ENSG00000204531 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: lung cancer 0.53 (GraphQL API, CC0))
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Location: Cytoplasm; Nucleus (UniProt). Locus 6p21.33 (HGNC).
RNA: tissue enhanced (kidney 17 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Caudate, Cerebellum, Cerebral cortex.
RNA cancer enriched: Testicular Germ Cell Tumor 401 pTPM.
Medium only: cervical cancer, colorectal cancer, endometrial cancer, head and neck cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"POU5F1" OR ABSTRACT:"POU5F1" OR TITLE:"POU class 5 homeobox 1" OR ABSTRACT:"POU class 5 homeobox 1" OR TITLE:"POU domain, class 5, transcription factor 1" OR ABSTRACT:"POU domain, class 5, transcription factor 1" OR TITLE:"OCT3" OR ABSTRACT:"OCT3" OR TITLE:"Oct4" OR ABSTRACT:"Oct4" OR TITLE:"MGC22487" OR ABSTRACT:"MGC22487") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POU5F1, not a curated reading list.