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POLE4 (DNA polymerase epsilon subunit 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.
In plain words · POLE4 (DNA polymerase epsilon subunit 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
POLE4 (DNA polymerase epsilon subunit 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.
No product in this corpus aims at POLE4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA POLE4: RNA low tissue specificity; high antibody staining in 7 normal tissues; highest cancer staining carcinoid (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas POLE4 tissue; Open Targets ENSG00000115350 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Li et al, J. Biol. Chem, 2000, "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". Source.
Sources: HGNC HGNC:18755 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NR33 (protein name, function text, keywords and locations (REST API)); CIViC gene POLE4 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Location: Nucleus (UniProt). Locus 2p12 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Bronchus, Caudate, Cerebral cortex, Colon, Endometrium, Epididymis, Fallopian tube.
Medium only: breast cancer, cervical cancer, lung cancer, lymphoma.
HPA POLE4 tissue · HPA POLE4 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"POLE4" OR ABSTRACT:"POLE4" OR TITLE:"DNA polymerase epsilon 4, accessory subunit" OR ABSTRACT:"DNA polymerase epsilon 4, accessory subunit" OR TITLE:"DNA polymerase epsilon subunit 4" OR ABSTRACT:"DNA polymerase epsilon subunit 4" OR TITLE:"p12" OR ABSTRACT:"p12") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POLE4, not a curated reading list.