{"entity":{"id":"pole4","kind":"target","name":"POLE4","aka":["DNA polymerase epsilon 4, accessory subunit","DNA polymerase epsilon subunit 4","p12"],"tldr":"POLE4 (DNA polymerase epsilon subunit 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18755","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18755"},{"label":"UniProt Q9NR33","url":"https://www.uniprot.org/uniprotkb/Q9NR33/entry"},{"label":"NCBI Gene 56655","url":"https://www.ncbi.nlm.nih.gov/gene/56655"},{"label":"Ensembl ENSG00000115350","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115350"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POLE4","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18755","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18755","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NR33","url":"https://www.uniprot.org/uniprotkb/Q9NR33/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene POLE4","url":"https://civicdb.org/features/13465","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA POLE4: RNA low tissue specificity; high antibody staining in 7 normal tissues; highest cancer staining carcinoid (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas POLE4 tissue","url":"https://www.proteinatlas.org/ENSG00000115350-POLE4/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000115350 associations","url":"https://platform.opentargets.org/target/ENSG00000115350/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18755","ensembl":"ENSG00000115350","uniprot":"Q9NR33","entrez":"56655","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Li et al, J. Biol. Chem, 2000, \"Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10801849/","biology":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Location: Nucleus (UniProt). Locus 2p12 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/pole4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}