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PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, affected pathway 0.61, genetic association 0.00, clinical 0.67).
In plain words · PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers.
No product in this corpus aims at PIK3R5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PIK3R5: RNA tissue enhanced (bone marrow 84 nTPM); no normal tissue stained high; highest cancer staining pancreatic cancer (3 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PIK3R5 tissue; Open Targets ENSG00000141506 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Yazaki et al, 1999, "Molecular cloning of a human novel gene, FOAP-2, which are highly expressed in macrophages". Source.
Sources: HGNC HGNC:30035 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WYR1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141506 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Location: Nucleus; Cytoplasm; Cell membrane (UniProt). Locus 17p13.1 (HGNC).
RNA: tissue enhanced (bone marrow 84 nTPM), detected in many normal tissues.
No normal tissue stained high.
Medium only: colorectal cancer, endometrial cancer, lung cancer, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PIK3R5" OR ABSTRACT:"PIK3R5" OR TITLE:"phosphoinositide-3-kinase regulatory subunit 5" OR ABSTRACT:"phosphoinositide-3-kinase regulatory subunit 5" OR TITLE:"Phosphoinositide 3-kinase regulatory subunit 5" OR ABSTRACT:"Phosphoinositide 3-kinase regulatory subunit 5" OR TITLE:"P101-PI3K" OR ABSTRACT:"P101-PI3K" OR TITLE:"p101" OR ABSTRACT:"p101") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PIK3R5, not a curated reading list.