{"entity":{"id":"pik3r5","kind":"target","name":"PIK3R5","aka":["phosphoinositide-3-kinase regulatory subunit 5","Phosphoinositide 3-kinase regulatory subunit 5","P101-PI3K","p101"],"tldr":"PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, affected pathway 0.61, genetic association 0.00, clinical 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30035"},{"label":"UniProt Q8WYR1","url":"https://www.uniprot.org/uniprotkb/Q8WYR1/entry"},{"label":"NCBI Gene 23533","url":"https://www.ncbi.nlm.nih.gov/gene/23533"},{"label":"Ensembl ENSG00000141506","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141506"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PIK3R5","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:30035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30035","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WYR1","url":"https://www.uniprot.org/uniprotkb/Q8WYR1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141506","url":"https://platform.opentargets.org/target/ENSG00000141506/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PIK3R5: RNA tissue enhanced (bone marrow 84 nTPM); no normal tissue stained high; highest cancer staining pancreatic cancer (3 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PIK3R5 tissue","url":"https://www.proteinatlas.org/ENSG00000141506-PIK3R5/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000141506 associations","url":"https://platform.opentargets.org/target/ENSG00000141506/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:30035","ensembl":"ENSG00000141506","uniprot":"Q8WYR1","entrez":"23533","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Yazaki et al, 1999, \"Molecular cloning of a human novel gene, FOAP-2, which are highly expressed in macrophages\".","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q8WYR1/entry","biology":"Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Location: Nucleus; Cytoplasm; Cell membrane (UniProt). Locus 17p13.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/pik3r5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}