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PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes clinical 0.67, affected pathway 0.76, literature 0.97, genetic association 0.49, somatic mutation 0.50).
In plain words · PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
No product in this corpus aims at PIK3R3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PIK3R3: RNA low tissue specificity; blood lineage group enriched (granulocytes 6 nTPM, monocytes 2 nTPM, T-cells 2 nTPM); high antibody staining in 10 normal tissues; highest cancer staining melanoma (1 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PIK3R3 tissue; Open Targets ENSG00000117461 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Suzuki, 1996, "Molecular cloning of human p55pik". Source.
Sources: HGNC HGNC:8981 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92569 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000117461 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Locus 1p34.1 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: group enriched (granulocytes 6 nTPM, monocytes 2 nTPM, T-cells 2 nTPM).
Medium: Adrenal gland, Bone marrow, Caudate, Cervix, Colon, Duodenum, Endometrium, Fallopian tube.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PIK3R3" OR ABSTRACT:"PIK3R3" OR TITLE:"phosphoinositide-3-kinase regulatory subunit 3" OR ABSTRACT:"phosphoinositide-3-kinase regulatory subunit 3" OR TITLE:"Phosphatidylinositol 3-kinase regulatory subunit gamma" OR ABSTRACT:"Phosphatidylinositol 3-kinase regulatory subunit gamma" OR TITLE:"p55" OR ABSTRACT:"p55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PIK3R3, not a curated reading list.