{"entity":{"id":"pik3r3","kind":"target","name":"PIK3R3","aka":["phosphoinositide-3-kinase regulatory subunit 3","Phosphatidylinositol 3-kinase regulatory subunit gamma","p55"],"tldr":"PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes clinical 0.67, affected pathway 0.76, literature 0.97, genetic association 0.49, somatic mutation 0.50).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8981","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8981"},{"label":"UniProt Q92569","url":"https://www.uniprot.org/uniprotkb/Q92569/entry"},{"label":"NCBI Gene 8503","url":"https://www.ncbi.nlm.nih.gov/gene/8503"},{"label":"Ensembl ENSG00000117461","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117461"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PIK3R3","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8981","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8981","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92569","url":"https://www.uniprot.org/uniprotkb/Q92569/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000117461","url":"https://platform.opentargets.org/target/ENSG00000117461/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA PIK3R3: RNA low tissue specificity; blood lineage group enriched (granulocytes 6 nTPM, monocytes 2 nTPM, T-cells 2 nTPM); high antibody staining in 10 normal tissues; highest cancer staining melanoma (1 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas PIK3R3 tissue","url":"https://www.proteinatlas.org/ENSG00000117461-PIK3R3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000117461 associations","url":"https://platform.opentargets.org/target/ENSG00000117461/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:8981","ensembl":"ENSG00000117461","uniprot":"Q92569","entrez":"8503","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Suzuki, 1996, \"Molecular cloning of human p55pik\".","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q92569/entry","biology":"Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Locus 1p34.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/pik3r3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}