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PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, animal model 0.29, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 5 cohorts (2 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Burkitt Lymphoma, Lung Adenocarcinoma.
In plain words · PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Location: Nucleus; Nucleus, nucleolus; Chromosome, centromere, kinetochore (UniProt).
No product in this corpus aims at PHF6 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:18145 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IWS0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156531 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.53, acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.61, myeloproliferative neoplasm 0.55, breast cancer 0.52, leukaemia 0.65 (GraphQL API, CC0)); IntOGen PHF6 (driver in 5 cohorts (Act 2, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Location: Nucleus; Nucleus, nucleolus; Chromosome, centromere, kinetochore (UniProt). Locus Xq26.2 (HGNC).
Query for this target: (TITLE:"PHF6" OR ABSTRACT:"PHF6" OR TITLE:"PHD finger protein 6" OR ABSTRACT:"PHD finger protein 6" OR TITLE:"KIAA1823" OR ABSTRACT:"KIAA1823" OR TITLE:"MGC14797" OR ABSTRACT:"MGC14797" OR TITLE:"CENP-31" OR ABSTRACT:"CENP-31") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHF6, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Burkitt lymphoma, Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Breast cancer (all types).