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PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Imatinib Mesylate and Sorafenib Tosylate. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes affected pathway 0.61, literature 0.97, genetic association 0.20, somatic mutation 0.97, animal model 0.47).
In plain words · PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin.
No product in this corpus aims at PDGFB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-specific alteration: the catalogues call it a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA PDGFB: RNA low tissue specificity; blood lineage lineage enriched (T-cells 10 nTPM); high antibody staining in 14 normal tissues; highest cancer staining prostate cancer (6 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P01127; CIViC gene PDGFB; Human Protein Atlas PDGFB tissue; Open Targets ENSG00000100311 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Waterfield M.D. et al, Nature, 1983, "Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus". Source.
Sources: HGNC HGNC:8800 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01127 (protein name, function text, keywords and locations (REST API)); CIViC gene PDGFB (3 evidence items, 0 assertions, 1 variants; diseases: Dermatofibrosarcoma Protuberans (GraphQL API, CC0)); Open Targets ENSG00000100311 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: sarcoma 0.63 (GraphQL API, CC0))
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signalling is modulated by the formation of heterodimers with PDGFA. Location: Secreted (UniProt). Locus 22q13.1 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: lineage enriched (T-cells 10 nTPM).
Medium: Adipose tissue, Adrenal gland, Bone marrow, Breast, Bronchus, Cerebral cortex, Cervix, Epididymis.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PDGFB" OR ABSTRACT:"PDGFB" OR TITLE:"platelet derived growth factor subunit B" OR ABSTRACT:"platelet derived growth factor subunit B" OR TITLE:"Platelet-derived growth factor subunit B" OR ABSTRACT:"Platelet-derived growth factor subunit B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDGFB, not a curated reading list.
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).
Shares Dermatofibrosarcoma protuberans, Sarcomas (soft tissue, bone, GIST).