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PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Gefitinib.
In plain words · PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
Phosphorylates MAP kinase p38. Seems to be active only in mitosis.
No product in this corpus aims at PBK yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PBK: RNA group enriched (lymphoid tissue 21 nTPM, testis 66 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PBK tissue; Open Targets ENSG00000168078 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Abe et al, J. Biol. Chem, 2000, "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells". Source.
Sources: HGNC HGNC:18282 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96KB5 (protein name, function text, keywords and locations (REST API)); CIViC gene PBK (2 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Gastric Adenocarcinoma (GraphQL API, CC0))
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilisation and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Locus 8p21.1 (HGNC).
RNA: group enriched (lymphoid tissue 21 nTPM, testis 66 nTPM), detected in many normal tissues.
Medium: Placenta.
No cancer stained high; medium in lymphoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PBK" OR ABSTRACT:"PBK" OR TITLE:"PDZ binding kinase" OR ABSTRACT:"PDZ binding kinase" OR TITLE:"Lymphokine-activated killer T-cell-originated protein kinase" OR ABSTRACT:"Lymphokine-activated killer T-cell-originated protein kinase" OR TITLE:"FLJ14385" OR ABSTRACT:"FLJ14385" OR TITLE:"Nori-3" OR ABSTRACT:"Nori-3" OR TITLE:"CT84" OR ABSTRACT:"CT84") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PBK, not a curated reading list.