{"entity":{"id":"pbk","kind":"target","name":"PBK","aka":["PDZ binding kinase","Lymphokine-activated killer T-cell-originated protein kinase","FLJ14385","Nori-3","CT84"],"tldr":"PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.","summary":"Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Gefitinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18282"},{"label":"UniProt Q96KB5","url":"https://www.uniprot.org/uniprotkb/Q96KB5/entry"},{"label":"NCBI Gene 55872","url":"https://www.ncbi.nlm.nih.gov/gene/55872"},{"label":"Ensembl ENSG00000168078","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168078"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PBK","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18282","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96KB5","url":"https://www.uniprot.org/uniprotkb/Q96KB5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PBK","url":"https://civicdb.org/features/13276","note":"2 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Gastric Adenocarcinoma (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PBK: RNA group enriched (lymphoid tissue 21 nTPM, testis 66 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PBK tissue","url":"https://www.proteinatlas.org/ENSG00000168078-PBK/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000168078 associations","url":"https://platform.opentargets.org/target/ENSG00000168078/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18282","ensembl":"ENSG00000168078","uniprot":"Q96KB5","entrez":"55872","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Abe et al, J. Biol. Chem, 2000, \"Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10781613/","biology":"Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilisation and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Locus 8p21.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/pbk/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}