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PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer.
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.96).
In plain words · PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer.
PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer.
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis.
No product in this corpus aims at PATZ1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Collins J.E. et al, 1999. Source.
Sources: HGNC HGNC:13071 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HBE1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100105 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.50, skin cancer 0.52 (GraphQL API, CC0))
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. Location: Nucleus (UniProt). Locus 22q12.2 (HGNC).
Query for this target: (TITLE:"PATZ1" OR ABSTRACT:"PATZ1" OR TITLE:"POZ/BTB and AT hook containing zinc finger 1" OR ABSTRACT:"POZ/BTB and AT hook containing zinc finger 1" OR TITLE:"POZ-, AT hook-, and zinc finger-containing protein 1" OR ABSTRACT:"POZ-, AT hook-, and zinc finger-containing protein 1" OR TITLE:"dJ400N23" OR ABSTRACT:"dJ400N23" OR TITLE:"ZBTB19" OR ABSTRACT:"ZBTB19" OR TITLE:"ZNF278" OR ABSTRACT:"ZNF278") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PATZ1, not a curated reading list.