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PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. Location: Nucleus (UniProt). Locus 22q12.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PATZ1" OR ABSTRACT:"PATZ1" OR TITLE:"POZ/BTB and AT hook containing zinc finger 1" OR ABSTRACT:"POZ/BTB and AT hook containing zinc finger 1" OR TITLE:"POZ-, AT hook-, and zinc finger-containing protein 1" OR ABSTRACT:"POZ-, AT hook-, and zinc finger-containing protein 1" OR TITLE:"dJ400N23" OR ABSTRACT:"dJ400N23" OR TITLE:"ZBTB19" OR ABSTRACT:"ZBTB19" OR TITLE:"ZNF278" OR ABSTRACT:"ZNF278") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PATZ1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/patz1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/patz1.json. Licence CC BY-NC 4.0.