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PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.89, genetic association 0.39).
In plain words · PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway.
No product in this corpus aims at PAPSS1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1997. Earliest sequence paper UniProt cites for the protein: Deyrup A.T., 1997, "Human ATP sulfurylase/APS kinase". Source.
Sources: HGNC HGNC:8603 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43252 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138801 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. Locus 4q25 (HGNC).
Query for this target: (TITLE:"PAPSS1" OR ABSTRACT:"PAPSS1" OR TITLE:"3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR ABSTRACT:"3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR TITLE:"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR ABSTRACT:"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR TITLE:"ATPSK1" OR ABSTRACT:"ATPSK1" OR TITLE:"PAPSS" OR ABSTRACT:"PAPSS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAPSS1, not a curated reading list.