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PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. Locus 4q25 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
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Query for this target: (TITLE:"PAPSS1" OR ABSTRACT:"PAPSS1" OR TITLE:"3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR ABSTRACT:"3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR TITLE:"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR ABSTRACT:"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1" OR TITLE:"ATPSK1" OR ABSTRACT:"ATPSK1" OR TITLE:"PAPSS" OR ABSTRACT:"PAPSS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAPSS1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/papss1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/papss1.json. Licence CC BY-NC 4.0.