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PAPPA2 (Pappalysin-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.
In plain words · PAPPA2 (Pappalysin-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
PAPPA2 (Pappalysin-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.
No product in this corpus aims at PAPPA2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PAPPA2: RNA tissue enriched (placenta 53 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PAPPA2 tissue; Open Targets ENSG00000116183 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Farr et al, Biochim. Biophys. Acta, 2000, "Pregnancy-associated plasma protein-E (PAPP-E)". Source.
Sources: HGNC HGNC:14615 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BXP8 (protein name, function text, keywords and locations (REST API)); CIViC gene PAPPA2 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Location: Secreted (UniProt). Locus 1q25.2 (HGNC).
RNA: tissue enriched (placenta 53 nTPM), detected in some normal tissues.
No normal tissue stained high; medium in Placenta, Testis.
RNA group enriched: Kidney Chromophobe 10 pTPM, Kidney Renal Papillary Cell Carcinoma 6 pTPM, Pancreatic Adenocarcinoma 3 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PAPPA2" OR ABSTRACT:"PAPPA2" OR TITLE:"pappalysin 2" OR ABSTRACT:"pappalysin 2" OR TITLE:"Pappalysin-2" OR ABSTRACT:"Pappalysin-2" OR TITLE:"PAPPE" OR ABSTRACT:"PAPPE" OR TITLE:"PAPP-A2" OR ABSTRACT:"PAPP-A2" OR TITLE:"PLAC3" OR ABSTRACT:"PLAC3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAPPA2, not a curated reading list.