{"entity":{"id":"pappa2","kind":"target","name":"PAPPA2","aka":["pappalysin 2","Pappalysin-2","PAPPE","PAPP-A2","PLAC3"],"tldr":"PAPPA2 (Pappalysin-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14615","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14615"},{"label":"UniProt Q9BXP8","url":"https://www.uniprot.org/uniprotkb/Q9BXP8/entry"},{"label":"NCBI Gene 60676","url":"https://www.ncbi.nlm.nih.gov/gene/60676"},{"label":"Ensembl ENSG00000116183","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116183"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PAPPA2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:14615","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14615","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BXP8","url":"https://www.uniprot.org/uniprotkb/Q9BXP8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PAPPA2","url":"https://civicdb.org/features/14195","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PAPPA2: RNA tissue enriched (placenta 53 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas PAPPA2 tissue","url":"https://www.proteinatlas.org/ENSG00000116183-PAPPA2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000116183 associations","url":"https://platform.opentargets.org/target/ENSG00000116183/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:14615","ensembl":"ENSG00000116183","uniprot":"Q9BXP8","entrez":"60676","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Farr et al, Biochim. Biophys. Acta, 2000, \"Pregnancy-associated plasma protein-E (PAPP-E)\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11018262/","biology":"Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Location: Secreted (UniProt). Locus 1q25.2 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/pappa2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}