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OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.
In plain words · OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer.
No product in this corpus aims at OVOL2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA OVOL2: RNA tissue enhanced (salivary gland 7 nTPM, stomach 1 7 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas OVOL2 tissue; Open Targets ENSG00000125850 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: 1999. Source.
Sources: HGNC HGNC:15804 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BRP0 (protein name, function text, keywords and locations (REST API)); CIViC gene OVOL2 (1 evidence items, 0 assertions, 1 variants; diseases: Glandular Pattern Ovarian Yolk Sac Tumour (GraphQL API, CC0))
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Location: Nucleus (UniProt). Locus 20p11.23 (HGNC).
RNA: tissue enhanced (salivary gland 7 nTPM, stomach 1 7 nTPM), detected in many normal tissues.
No normal tissue stained high.
No cancer stained high; medium in breast cancer, cervical cancer, glioma, lung cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"OVOL2" OR ABSTRACT:"OVOL2" OR TITLE:"ovo like zinc finger 2" OR ABSTRACT:"ovo like zinc finger 2" OR TITLE:"Transcription factor Ovo-like 2" OR ABSTRACT:"Transcription factor Ovo-like 2" OR TITLE:"bA504H3.3" OR ABSTRACT:"bA504H3.3" OR TITLE:"HOVO2" OR ABSTRACT:"HOVO2" OR TITLE:"ZNF339" OR ABSTRACT:"ZNF339") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OVOL2, not a curated reading list.