{"entity":{"id":"ovol2","kind":"target","name":"OVOL2","aka":["ovo like zinc finger 2","Transcription factor Ovo-like 2","bA504H3.3","HOVO2","ZNF339","CHED1"],"tldr":"OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15804","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15804"},{"label":"UniProt Q9BRP0","url":"https://www.uniprot.org/uniprotkb/Q9BRP0/entry"},{"label":"NCBI Gene 58495","url":"https://www.ncbi.nlm.nih.gov/gene/58495"},{"label":"Ensembl ENSG00000125850","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125850"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glandular Pattern Ovarian Yolk Sac Tumour."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"OVOL2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:15804","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15804","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BRP0","url":"https://www.uniprot.org/uniprotkb/Q9BRP0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene OVOL2","url":"https://civicdb.org/features/14079","note":"1 evidence items, 0 assertions, 1 variants; diseases: Glandular Pattern Ovarian Yolk Sac Tumour (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA OVOL2: RNA tissue enhanced (salivary gland 7 nTPM, stomach 1 7 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas OVOL2 tissue","url":"https://www.proteinatlas.org/ENSG00000125850-OVOL2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000125850 associations","url":"https://platform.opentargets.org/target/ENSG00000125850/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:15804","ensembl":"ENSG00000125850","uniprot":"Q9BRP0","entrez":"58495","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: 1999.","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q9BRP0/entry","biology":"Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Location: Nucleus (UniProt). Locus 20p11.23 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/ovol2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}