Loading
OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.89, literature 0.98, genetic association 0.01, somatic mutation 0.55, animal model 0.74).
In plain words · OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA.
No product in this corpus aims at OGG1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1997. Earliest sequence paper UniProt cites for the protein: Aburatani et al, Cancer Res, 1997, "Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue". Source.
Sources: HGNC HGNC:8125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15527 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114026 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Location: Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus (UniProt). Locus 3p25.3 (HGNC).
Query for this target: (TITLE:"OGG1" OR ABSTRACT:"OGG1" OR TITLE:"8-oxoguanine DNA glycosylase" OR ABSTRACT:"8-oxoguanine DNA glycosylase" OR TITLE:"N-glycosylase/DNA lyase" OR ABSTRACT:"N-glycosylase/DNA lyase" OR TITLE:"HOGG1" OR ABSTRACT:"HOGG1" OR TITLE:"OGH1" OR ABSTRACT:"OGH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OGG1, not a curated reading list.