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OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Location: Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus (UniProt). Locus 3p25.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"OGG1" OR ABSTRACT:"OGG1" OR TITLE:"8-oxoguanine DNA glycosylase" OR ABSTRACT:"8-oxoguanine DNA glycosylase" OR TITLE:"N-glycosylase/DNA lyase" OR ABSTRACT:"N-glycosylase/DNA lyase" OR TITLE:"HOGG1" OR ABSTRACT:"HOGG1" OR TITLE:"OGH1" OR ABSTRACT:"OGH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OGG1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ogg1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ogg1.json. Licence CC BY-NC 4.0.