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NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mercaptopurine, Thioguanine and Azathioprine. In OnCo, 1 product record names it (Mercaptopurine).
In plain words · NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP.
No product in this corpus aims at NUDT15 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Mercaptopurine) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA NUDT15: RNA low tissue specificity; high antibody staining in 25 normal tissues; highest cancer staining endometrial cancer (6 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NUDT15 tissue; Open Targets ENSG00000136159 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:23063 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NV35 (protein name, function text, keywords and locations (REST API)); CIViC gene NUDT15 (1 evidence items, 0 assertions, 1 variants; diseases: Childhood Acute Lymphocytic Leukaemia (GraphQL API, CC0))
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitising role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilising PCNA. Locus 13q14.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Appendix, Caudate, Cervix, Epididymis, Gallbladder, Heart muscle, Hippocampus.
Medium only: cervical cancer, glioma, liver cancer, lung cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NUDT15" OR ABSTRACT:"NUDT15" OR TITLE:"nudix hydrolase 15" OR ABSTRACT:"nudix hydrolase 15" OR TITLE:"Nucleotide triphosphate diphosphatase NUDT15" OR ABSTRACT:"Nucleotide triphosphate diphosphatase NUDT15" OR TITLE:"MTH2" OR ABSTRACT:"MTH2" OR TITLE:"FLJ10956" OR ABSTRACT:"FLJ10956") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUDT15, not a curated reading list.