{"entity":{"id":"nudt15","kind":"target","name":"NUDT15","aka":["nudix hydrolase 15","Nucleotide triphosphate diphosphatase NUDT15","MTH2","FLJ10956"],"tldr":"NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.","summary":"Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mercaptopurine, Thioguanine and Azathioprine. In OnCo, 1 product record names it (Mercaptopurine).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23063","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23063"},{"label":"UniProt Q9NV35","url":"https://www.uniprot.org/uniprotkb/Q9NV35/entry"},{"label":"NCBI Gene 55270","url":"https://www.ncbi.nlm.nih.gov/gene/55270"},{"label":"Ensembl ENSG00000136159","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136159"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["mercaptopurine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Childhood Acute Lymphocytic Leukaemia."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NUDT15","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:23063","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23063","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NV35","url":"https://www.uniprot.org/uniprotkb/Q9NV35/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NUDT15","url":"https://civicdb.org/features/12881","note":"1 evidence items, 0 assertions, 1 variants; diseases: Childhood Acute Lymphocytic Leukaemia (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"not-established","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Mercaptopurine) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA NUDT15: RNA low tissue specificity; high antibody staining in 25 normal tissues; highest cancer staining endometrial cancer (6 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas NUDT15 tissue","url":"https://www.proteinatlas.org/ENSG00000136159-NUDT15/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000136159 associations","url":"https://platform.opentargets.org/target/ENSG00000136159/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:23063","ensembl":"ENSG00000136159","uniprot":"Q9NV35","entrez":"55270","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, \"Complete sequencing and characterization of 21,243 full-length human cDNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14702039/","biology":"Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitising role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilising PCNA. Locus 13q14.2 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/nudt15/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"drug":[{"id":"mercaptopurine","kind":"drug","name":"Mercaptopurine","route":"/drugs/mercaptopurine/"}]}}