Loading
NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.76, genetic association 0.42, clinical 0.12).
In plain words · NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide.
No product in this corpus aims at NOX4 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NOX4: RNA group enriched (blood vessel 35 nTPM, kidney 129 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas NOX4 tissue; Open Targets ENSG00000086991 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Geiszt et al, Proc. Natl. Acad. Sci. U.S.A, 2000, "Identification of renox, an NAD(P)H oxidase in kidney". Source.
Sources: HGNC HGNC:7891 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPH5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000086991 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signalling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Location: Cytoplasm; Endoplasmic reticulum membrane; Cell membrane; Cell junction, focal adhesion (UniProt). Locus 11q14.3 (HGNC).
RNA: group enriched (blood vessel 35 nTPM, kidney 129 nTPM), detected in many normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NOX4" OR ABSTRACT:"NOX4" OR TITLE:"NADPH oxidase 4" OR ABSTRACT:"NADPH oxidase 4" OR TITLE:"KOX-1" OR ABSTRACT:"KOX-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NOX4, not a curated reading list.