{"entity":{"id":"nox4","kind":"target","name":"NOX4","aka":["NADPH oxidase 4","KOX-1"],"tldr":"NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.76, genetic association 0.42, clinical 0.12).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7891","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7891"},{"label":"UniProt Q9NPH5","url":"https://www.uniprot.org/uniprotkb/Q9NPH5/entry"},{"label":"NCBI Gene 50507","url":"https://www.ncbi.nlm.nih.gov/gene/50507"},{"label":"Ensembl ENSG00000086991","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086991"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NOX4","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7891","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7891","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NPH5","url":"https://www.uniprot.org/uniprotkb/Q9NPH5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000086991","url":"https://platform.opentargets.org/target/ENSG00000086991/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NOX4: RNA group enriched (blood vessel 35 nTPM, kidney 129 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas NOX4 tissue","url":"https://www.proteinatlas.org/ENSG00000086991-NOX4/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000086991 associations","url":"https://platform.opentargets.org/target/ENSG00000086991/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7891","ensembl":"ENSG00000086991","uniprot":"Q9NPH5","entrez":"50507","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Geiszt et al, Proc. Natl. Acad. Sci. U.S.A, 2000, \"Identification of renox, an NAD(P)H oxidase in kidney\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10869423/","biology":"NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signalling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Location: Cytoplasm; Endoplasmic reticulum membrane; Cell membrane; Cell junction, focal adhesion (UniProt). Locus 11q14.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/nox4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}