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NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.96, animal model 0.88, genetic association 0.61).
In plain words · NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor.
No product in this corpus aims at NKX3-1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: He W.-W. et al, Genomics, 1997, "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer". Source.
Sources: HGNC HGNC:7838 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99801 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167034 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 2-16% | Deep deletion (8p21) | cBioPortal deep deletion: 53 of 333, 15.9%, in prad_tcga_pub; 39 of 489, 8.0%, in prad_tcga_pan_can_atlas_2018; 44 of 1,013, 4.3%, in prad_p1000; 12 of 424, 2.8%, in prad_mcspc_mskcc_2020; 61 of 2,260, 2.7%, in prostate_msk_2024; 11 of 444, 2.5%, in prad_su2c_2019; 8 of 61, 13.1%, in prad_mich. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Query for this target: (TITLE:"NKX3-1" OR ABSTRACT:"NKX3-1" OR TITLE:"NK3 homeobox 1" OR ABSTRACT:"NK3 homeobox 1" OR TITLE:"Homeobox protein Nkx-3.1" OR ABSTRACT:"Homeobox protein Nkx-3.1" OR TITLE:"NKX3.1" OR ABSTRACT:"NKX3.1" OR TITLE:"BAPX2" OR ABSTRACT:"BAPX2" OR TITLE:"NKX3A" OR ABSTRACT:"NKX3A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NKX3-1, not a curated reading list.
Shares Prostate cancer (KEGG map), Open Targets Platform, Prostate cancer.
Shares Prostate cancer (KEGG map), Open Targets Platform, Prostate cancer.