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NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 2-16% | Deep deletion (8p21) | cBioPortal deep deletion: 53 of 333, 15.9%, in prad_tcga_pub; 39 of 489, 8.0%, in prad_tcga_pan_can_atlas_2018; 44 of 1,013, 4.3%, in prad_p1000; 12 of 424, 2.8%, in prad_mcspc_mskcc_2020; 61 of 2,260, 2.7%, in prostate_msk_2024; 11 of 444, 2.5%, in prad_su2c_2019; 8 of 61, 13.1%, in prad_mich. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"NKX3-1" OR ABSTRACT:"NKX3-1" OR TITLE:"NK3 homeobox 1" OR ABSTRACT:"NK3 homeobox 1" OR TITLE:"Homeobox protein Nkx-3.1" OR ABSTRACT:"Homeobox protein Nkx-3.1" OR TITLE:"NKX3.1" OR ABSTRACT:"NKX3.1" OR TITLE:"BAPX2" OR ABSTRACT:"BAPX2" OR TITLE:"NKX3A" OR ABSTRACT:"NKX3A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NKX3-1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/nkx3-1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nkx3-1.json. Licence CC BY-NC 4.0.