Loading
NDRG1 (N-myc downstream regulated 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Lung cancer, Colorectal cancer and 1 more.
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumour suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, animal model 0.44, genetic association 0.00, somatic mutation 0.98).
In plain words · NDRG1 (N-myc downstream regulated 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Lung cancer, Colorectal cancer and 1 more.
NDRG1 (N-myc downstream regulated 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Lung cancer, Colorectal cancer and 1 more.
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumour suppressor in many cell types.
No product in this corpus aims at NDRG1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Kokame et al, J. Biol. Chem, 1996, "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". Source.
Sources: HGNC HGNC:7679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92597 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104419 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.52, gastric cancer 0.51, breast cancer 0.54, lung cancer 0.53 (GraphQL API, CC0))
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumour suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Cell membrane (UniProt). Locus 8q24.22 (HGNC).
Query for this target: (TITLE:"NDRG1" OR ABSTRACT:"NDRG1" OR TITLE:"N-myc downstream regulated 1" OR ABSTRACT:"N-myc downstream regulated 1" OR TITLE:"DRG1" OR ABSTRACT:"DRG1" OR TITLE:"TDD5" OR ABSTRACT:"TDD5" OR TITLE:"NDR1" OR ABSTRACT:"NDR1" OR TITLE:"CAP43" OR ABSTRACT:"CAP43") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NDRG1, not a curated reading list.