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NCOA3 (Nuclear receptor coactivator 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Colorectal cancer.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).
CIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming PD-1 Ligand Inhibitor and Anti-PDL1 Therapy.
In plain words · NCOA3 (Nuclear receptor coactivator 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Colorectal cancer.
NCOA3 (Nuclear receptor coactivator 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Colorectal cancer.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
No product in this corpus aims at NCOA3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NCOA3: RNA low tissue specificity; high antibody staining in 1 normal tissue; highest cancer staining lung cancer (1 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NCOA3 tissue; Open Targets ENSG00000124151 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Takeshita et al, J. Biol. Chem, 1997, "TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". Source.
Sources: HGNC HGNC:7670 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6Q9 (protein name, function text, keywords and locations (REST API)); CIViC gene NCOA3 (3 evidence items, 0 assertions, 3 variants; diseases: Breast Cancer, Colon Adenocarcinoma (GraphQL API, CC0))
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.12 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Cerebellum, Cerebral cortex.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NCOA3" OR ABSTRACT:"NCOA3" OR TITLE:"nuclear receptor coactivator 3" OR ABSTRACT:"nuclear receptor coactivator 3" OR TITLE:"Nuclear receptor coactivator 3" OR ABSTRACT:"Nuclear receptor coactivator 3" OR TITLE:"RAC3" OR ABSTRACT:"RAC3" OR TITLE:"AIB1" OR ABSTRACT:"AIB1" OR TITLE:"p/CIP" OR ABSTRACT:"p/CIP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOA3, not a curated reading list.