{"entity":{"id":"ncoa3","kind":"target","name":"NCOA3","aka":["nuclear receptor coactivator 3","Nuclear receptor coactivator 3","RAC3","AIB1","p/CIP","TRAM-1","CAGH16","TNRC16","KAT13B","bHLHe42","SRC-3","SRC3"],"tldr":"NCOA3 (Nuclear receptor coactivator 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Colorectal cancer.","summary":"Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).\n\nCIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming PD-1 Ligand Inhibitor and Anti-PDL1 Therapy.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7670"},{"label":"UniProt Q9Y6Q9","url":"https://www.uniprot.org/uniprotkb/Q9Y6Q9/entry"},{"label":"NCBI Gene 8202","url":"https://www.ncbi.nlm.nih.gov/gene/8202"},{"label":"Ensembl ENSG00000124151","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124151"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NCOA3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7670","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7670","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6Q9","url":"https://www.uniprot.org/uniprotkb/Q9Y6Q9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene NCOA3","url":"https://civicdb.org/features/74","note":"3 evidence items, 0 assertions, 3 variants; diseases: Breast Cancer, Colon Adenocarcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"few-types","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NCOA3: RNA low tissue specificity; high antibody staining in 1 normal tissue; highest cancer staining lung cancer (1 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas NCOA3 tissue","url":"https://www.proteinatlas.org/ENSG00000124151-NCOA3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000124151 associations","url":"https://platform.opentargets.org/target/ENSG00000124151/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7670","ensembl":"ENSG00000124151","uniprot":"Q9Y6Q9","entrez":"8202","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Takeshita et al, J. Biol. Chem, 1997, \"TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9346901/","biology":"Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.12 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease","Colorectal cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ncoa3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}