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MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.
CIViC holds 3 clinical evidence items and 1 assertion across 1 variant.
In plain words · MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'.
No product in this corpus aims at MYBL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MYBL1: RNA tissue enhanced (lymphoid tissue 19 nTPM, testis 11 nTPM); blood lineage lineage enhanced (T-cells 2 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MYBL1 tissue; Open Targets ENSG00000185697 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Nomura et al, Nucleic Acids Res, 1988, "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb". Source.
Sources: HGNC HGNC:7547 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10243 (protein name, function text, keywords and locations (REST API)); CIViC gene MYBL1 (3 evidence items, 1 assertions, 1 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered (GraphQL API, CC0))
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30. Location: Nucleus (UniProt). Locus 8q13.1 (HGNC).
RNA: tissue enhanced (lymphoid tissue 19 nTPM, testis 11 nTPM), detected in many normal tissues. Blood: lineage enhanced (T-cells 2 nTPM).
No normal tissue stained high.
No cancer stained high; medium in carcinoid.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MYBL1" OR ABSTRACT:"MYBL1" OR TITLE:"MYB proto-oncogene like 1" OR ABSTRACT:"MYB proto-oncogene like 1" OR TITLE:"Myb-related protein A" OR ABSTRACT:"Myb-related protein A" OR TITLE:"A-myb" OR ABSTRACT:"A-myb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYBL1, not a curated reading list.