{"entity":{"id":"mybl1","kind":"target","name":"MYBL1","aka":["MYB proto-oncogene like 1","Myb-related protein A","A-myb"],"tldr":"MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.\n\nCIViC holds 3 clinical evidence items and 1 assertion across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7547","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7547"},{"label":"UniProt P10243","url":"https://www.uniprot.org/uniprotkb/P10243/entry"},{"label":"NCBI Gene 4603","url":"https://www.ncbi.nlm.nih.gov/gene/4603"},{"label":"Ensembl ENSG00000185697","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185697"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYBL1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7547","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7547","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10243","url":"https://www.uniprot.org/uniprotkb/P10243/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MYBL1","url":"https://civicdb.org/features/3731","note":"3 evidence items, 1 assertions, 1 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MYBL1: RNA tissue enhanced (lymphoid tissue 19 nTPM, testis 11 nTPM); blood lineage lineage enhanced (T-cells 2 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MYBL1 tissue","url":"https://www.proteinatlas.org/ENSG00000185697-MYBL1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000185697 associations","url":"https://platform.opentargets.org/target/ENSG00000185697/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7547","ensembl":"ENSG00000185697","uniprot":"P10243","entrez":"4603","firstDescribed":1988,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nomura et al, Nucleic Acids Res, 1988, \"Isolation of human cDNA clones of myb-related genes, A-myb and B-myb\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3060855/","biology":"Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30. Location: Nucleus (UniProt). Locus 8q13.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/mybl1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}