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MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.24, affected pathway 0.89, genetic association 0.78, somatic mutation 0.68).
In plain words · MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1.
No product in this corpus aims at MPRIP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2002. Earliest sequence paper UniProt cites for the protein: Inazawa et al, 2002, "Cloning of human orthologue RHOIP3 of Mus Rhoip3". Source.
Sources: HGNC HGNC:30321 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6WCQ1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000133030 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.64, renal cell carcinoma 0.62 (GraphQL API, CC0))
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibres in neuronal cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17p11.2 (HGNC).
Query for this target: (TITLE:"MPRIP" OR ABSTRACT:"MPRIP" OR TITLE:"myosin phosphatase Rho interacting protein" OR ABSTRACT:"myosin phosphatase Rho interacting protein" OR TITLE:"Myosin phosphatase Rho-interacting protein" OR ABSTRACT:"Myosin phosphatase Rho-interacting protein" OR TITLE:"RHOIP3" OR ABSTRACT:"RHOIP3" OR TITLE:"M-RIP" OR ABSTRACT:"M-RIP" OR TITLE:"p116Rip" OR ABSTRACT:"p116Rip") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MPRIP, not a curated reading list.