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MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Bevacizumab. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 1.00, animal model 0.79, genetic association 0.56, clinical 0.66).
In plain words · MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.
No product in this corpus aims at MMP2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MMP2: RNA tissue enhanced (gallbladder 994 nTPM); high antibody staining in 3 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MMP2 tissue; Open Targets ENSG00000087245 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Collier I.E. et al, J. Biol. Chem, 1988, "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". Source.
Sources: HGNC HGNC:7166 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08253 (protein name, function text, keywords and locations (REST API)); CIViC gene MMP2 (2 evidence items, 0 assertions, 1 variants; diseases: Brain Glioma, Inflammatory Breast Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000087245 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Location: Secreted, extracellular space, extracellular matrix; Membrane; Nucleus; Cytoplasm (UniProt). Locus 16q12.2 (HGNC).
RNA: tissue enhanced (gallbladder 994 nTPM), detected in all normal tissues.
Medium: Endometrium, Fallopian tube, Lung, Urinary bladder.
No cancer stained high; medium in cervical cancer, endometrial cancer, pancreatic cancer, prostate cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MMP2" OR ABSTRACT:"MMP2" OR TITLE:"matrix metallopeptidase 2" OR ABSTRACT:"matrix metallopeptidase 2" OR TITLE:"72 kDa type IV collagenase" OR ABSTRACT:"72 kDa type IV collagenase" OR TITLE:"MMP-2" OR ABSTRACT:"MMP-2" OR TITLE:"TBE-1" OR ABSTRACT:"TBE-1" OR TITLE:"CLG4" OR ABSTRACT:"CLG4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MMP2, not a curated reading list.